Transcription factor regulation of eQTL activity across individuals and tissues.

Tens of thousands of genetic variants associated with gene expression (cis-eQTLs) have been discovered in the human population. These eQTLs are active in various tissues and contexts, but the molecular mechanisms of eQTL variability are poorly understood, hindering our understanding of genetic regul...

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Bibliographic Details
Main Authors: Elise D Flynn, Athena L Tsu, Silva Kasela, Sarah Kim-Hellmuth, Francois Aguet, Kristin G Ardlie, Harmen J Bussemaker, Pejman Mohammadi, Tuuli Lappalainen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1009719