Thiocholine-Mediated One-Pot Peptide Ligation and Desulfurization

Thiocholine-Mediated One-Pot Peptide Ligation and Desulfurization

Thiol catalysts are essential in native chemical ligation (NCL) to increase the reaction efficiency. In this paper, we report the use of thiocholine in chemical protein synthesis, including NCL-based peptide ligation and metal-free desulfurization. Evaluation of thiocholine peptide thioester in term...

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Bibliographic Details
Main Authors: Sae Suzuki, Yuya Nakajima, Naoki Kamo, Akihisa Osakabe, Akimitsu Okamoto, Gosuke Hayashi, Hiroshi Murakami
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Molecules
Subjects:
chemical protein synthesis
native chemical ligation
desulfurization
one-pot synthesis
Online Access:https://www.mdpi.com/1420-3049/28/9/3655

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https://www.mdpi.com/1420-3049/28/9/3655

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