Protection of Cholinergic Neurons against Zinc Toxicity by Glial Cells in Thiamine-Deficient Media

Protection of Cholinergic Neurons against Zinc Toxicity by Glial Cells in Thiamine-Deficient Media

Brain pathologies evoked by thiamine deficiency can be aggravated by mild zinc excess. Cholinergic neurons are the most susceptible to such cytotoxic signals. Sub-toxic zinc excess aggravates the injury of neuronal SN56 cholinergic cells under mild thiamine deficiency. The excessive cell loss is cau...

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Bibliographic Details
Main Authors: Sylwia Gul-Hinc, Anna Michno, Marlena Zyśk, Andrzej Szutowicz, Agnieszka Jankowska-Kulawy, Anna Ronowska
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
zinc toxicity
acetyl-CoA
energy metabolism
thiamine pyrophosphate
Online Access:https://www.mdpi.com/1422-0067/22/24/13337

Internet

https://www.mdpi.com/1422-0067/22/24/13337

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