Determining distinct roles of IL-1α through generation of an IL-1α knockout mouse with no defect in IL-1β expression

Determining distinct roles of IL-1α through generation of an IL-1α knockout mouse with no defect in IL-1β expression

Interleukin 1α (IL-1α) and IL-1β are the founding members of the IL-1 cytokine family, and these innate immune inflammatory mediators are critically important in health and disease. Early studies on these molecules suggested that their expression was interdependent, with an initial genetic model of...

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Bibliographic Details
Main Authors: R.K. Subbarao Malireddi, Ratnakar R. Bynigeri, Balabhaskararao Kancharana, Bhesh Raj Sharma, Amanda R. Burton, Stephane Pelletier, Thirumala-Devi Kanneganti
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Immunology
Subjects:
PAMP
innate immunity
inflammation
inflammasome
IL-1α
IL-1β
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1068230/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.1068230/full

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