Osteoprotegerin Prevents Intracranial Aneurysm Progression by Promoting Collagen Biosynthesis and Vascular Smooth Muscle Cell Proliferation

Osteoprotegerin Prevents Intracranial Aneurysm Progression by Promoting Collagen Biosynthesis and Vascular Smooth Muscle Cell Proliferation

Background Decreased extracellular matrix formation and few vascular smooth muscle cells (VSMCs) in cerebral vascular walls are the main characteristics of intracranial aneurysm (IA) pathogenesis. Recently, osteoprotegerin was reported to activate collagen biosynthesis and VSMC proliferation via the...

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Bibliographic Details
Main Authors: Takeshi Miyata, Manabu Minami, Hiroharu Kataoka, Kosuke Hayashi, Taichi Ikedo, Tao Yang, Yu Yamamoto, Masayuki Yokode, Susumu Miyamoto
Format: Article
Language:English
Published: Wiley 2020-09-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
cell proliferation
collagen
intracranial aneurysm
osteoprotegerin
transforming growth factor‐β1
vascular smooth muscle cell
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.119.015731

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.119.015731

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