Methadone interrupts neural growth and function in human cortical organoids

Prenatal opioids exposure can lead to both neonatal abstinence syndrome in newborns and neurological deficits later in life. Although opioids have been well studied in general, the cellular and molecular mechanisms by which opioids affect human fetal brain development has not been well understood. I...

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Bibliographic Details
Main Authors: Hang Yao, Wei Wu, Ines Cerf, Helen W. Zhao, Juan Wang, Priscilla D. Negraes, Alysson R. Muotri, Gabriel G. Haddad
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Stem Cell Research
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506120303664