Neuroprotective effect of astragalin via activating PI3K/Akt-mTOR-mediated autophagy on APP/PS1 mice

Abstract As a small molecule flavonoid, astragalin (AST) has anti-inflammatory, anti-cancer, and anti-oxidation effects. However, the impact and molecular mechanism of AST in Alzheimer’s disease (AD) are still not clear. This study aims to investigate the neuroprotective effect and mechanism of AST...

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Bibliographic Details
Main Authors: Cui-Zhu Yang, Shu-Han Wang, Run-Heng Zhang, Jia-Hong Lin, Ying-Hong Tian, Ya-Qi Yang, Jing Liu, Yu-Xin Ma
Format: Article
Language:English
Published: Nature Publishing Group 2023-01-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-023-01324-1