Myo1d promotes alpha-synuclein transfer from brain microvascular endothelial cells to pericytes through tunneling nanotubes

Myo1d promotes alpha-synuclein transfer from brain microvascular endothelial cells to pericytes through tunneling nanotubes

Summary: α-Synuclein preformed fibrils (α-syn PFF) in the blood can cross the blood–brain barrier and invade the central nervous system. Our previous study proved that α-syn PFF can be taken up by brain microvascular endothelial cells (BMVECs). Here, we found that α-syn PFF spread from BMVECs to per...

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Bibliographic Details
Main Authors: Qingrui Duan, Qingxi Zhang, Kun Nie, Rui Huang, Jianhua Yang, Peikun He, Zihui Tie, Haifeng Huang, Guixian Ma, Yuhu Zhang, Yuyuan Gao, Lijuan Wang
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:iScience
Subjects:
Neuroscience
Molecular neuroscience
Cellular neuroscience
Omics
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223015353

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http://www.sciencedirect.com/science/article/pii/S2589004223015353

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