Immune escape pathways from the HBV core18-27 CD8 T cell response are driven by individual HLA class I alleles

Immune escape pathways from the HBV core18-27 CD8 T cell response are driven by individual HLA class I alleles

Background and aimsThere is growing interest in T cell-based immune therapies for a functional cure of chronic HBV infection including check-point inhibition, T cell-targeted vaccines or TCR-grafted effector cells. All these approaches depend on recognition of HLA class I-presented viral peptides. T...

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Bibliografske podrobnosti
Main Authors: Andreas Walker, Tatjana Schwarz, Janine Brinkmann-Paulukat, Karin Wisskirchen, Christopher Menne, Elahe Salimi Alizei, Helenie Kefalakes, Martin Theissen, Daniel Hoffmann, Julian Schulze zur Wiesch, Mala K. Maini, Markus Cornberg, Anke RM Kraft, Verena Keitel, Hans H. Bock, Peter A. Horn, Robert Thimme, Heiner Wedemeyer, Falko M. Heinemann, Tom Luedde, Christoph Neumann-Haefelin, Ulrike Protzer, Jörg Timm
Format: Article
Jezik:English
Izdano: Frontiers Media S.A. 2022-11-01
Serija:Frontiers in Immunology
Teme:
hepatitis B virus
CD8 T cell response
TCR-engineered T cells
immune escape
chronic infection
Online dostop:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1045498/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1045498/full

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