Multivariate extension of penalized regression on summary statistics to construct polygenic risk scores for correlated traits

Multivariate extension of penalized regression on summary statistics to construct polygenic risk scores for correlated traits

Summary: Genetic correlations between human traits and disorders such as schizophrenia (SZ) and bipolar disorder (BD) diagnoses are well established. Improved prediction of individual traits has been obtained by combining predictors of multiple genetically correlated traits derived from summary stat...

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Bibliografske podrobnosti
Main Authors: Meriem Bahda, Jasmin Ricard, Simon L. Girard, Michel Maziade, Maripier Isabelle, Alexandre Bureau
Format: Article
Jezik:English
Izdano: Elsevier 2023-07-01
Serija:HGG Advances
Teme:
bipolar disorder
elastic net
genetic covariance
heritability models
LASSO
multivariate linear mixed model
Online dostop:http://www.sciencedirect.com/science/article/pii/S2666247723000416

Internet

http://www.sciencedirect.com/science/article/pii/S2666247723000416

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