tPA deficiency in mice leads to rearrangement in the cerebrovascular tree and cerebroventricular malformations

tPA deficiency in mice leads to rearrangement in the cerebrovascular tree and cerebroventricular malformations

The serine protease tissue-type plasminogen activator (tPA) is used as a thrombolytic agent in the management of ischemic stroke, but concerns for hemorrhagic conversion greatly limits the number of patients that receive this treatment. It has been suggested that the bleeding complications associate...

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Bibliographic Details
Main Authors: Christina eStefanitsch, Anna-Lisa E. Lawrence, Anna eOlverling, Ingrid eNilsson, Linda eFredriksson
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-11-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Lateral Ventricles
Platelet-Derived Growth Factor
Tissue Plasminogen Activator
neurovascular coupling
neurovascular unit
Vascular permeability
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00456/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00456/full

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