Accelerated cystogenesis by dietary protein load is dependent on, but not initiated by kidney macrophages

Accelerated cystogenesis by dietary protein load is dependent on, but not initiated by kidney macrophages

BackgroundDisease severity of autosomal dominant polycystic kidney disease (ADPKD) is influenced by diet. Dietary protein, a recognized cyst-accelerating factor, is catabolized into amino acids (AA) and delivered to the kidney leading to renal hypertrophy. Injury-induced hypertrophic signaling in AD...

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Bibliographic Details
Main Authors: Randee Sedaka, Jifeng Huang, Shinobu Yamaguchi, Caleb Lovelady, Jung-Shan Hsu, Sejal Shinde, Malgorzata Kasztan, David K. Crossman, Takamitsu Saigusa
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Medicine
Subjects:
polycystic kidney disease
high protein
glutamine
renal hypertophy
macrophage
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2023.1173674/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2023.1173674/full

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