CD36-mediated metabolic crosstalk between tumor cells and macrophages affects liver metastasis

CD36-mediated metabolic crosstalk between tumor cells and macrophages affects liver metastasis

Macrophage-mediated immune suppression contributes to poor outcome in liver metastasis. Here the authors show that CD36-expressing metastasis associated macrophages engulf tumor cell-derived extracellular vesicles enriched in long-chain fatty acids, acquiring a pro-tumorigenic phenotype in a preclin...

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Bibliographic Details
Main Authors: Ping Yang, Hong Qin, Yiyu Li, Anhua Xiao, Enze Zheng, Han Zeng, Chunxiao Su, Xiaoqing Luo, Qiannan Lu, Meng Liao, Lei Zhao, Li Wei, Zac Varghese, John F. Moorhead, Yaxi Chen, Xiong Z. Ruan
Format: Article
Language:English
Published: Nature Portfolio 2022-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-33349-y

Internet

https://doi.org/10.1038/s41467-022-33349-y

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