Detection of Germline Mutations in a Cohort of 250 Relatives of Mutation Carriers in Multigene Panel: Impact of Pathogenic Variants in Other Genes beyond <i>BRCA1/2</i>

Detection of Germline Mutations in a Cohort of 250 Relatives of Mutation Carriers in Multigene Panel: Impact of Pathogenic Variants in Other Genes beyond <i>BRCA1/2</i>

Background: Several hereditary–familial syndromes associated with various types of tumors have been identified to date, evidencing that hereditary cancers caused by germline mutations account for 5–10% of all tumors. Advances in genetic technology and the implementation of Next-Generation Sequencing...

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Bibliographic Details
Main Authors: Sara Di Rado, Roberta Giansante, Michela Cicirelli, Lucrezia Pilenzi, Anastasia Dell’Elice, Federico Anaclerio, Martina Rimoldi, Antonino Grassadonia, Simona Grossi, Nicole Canale, Patrizia Ballerini, Liborio Stuppia, Ivana Antonucci
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Cancers
Subjects:
NGS multigene panel
hereditary cancer
healthy collateral family members
Online Access:https://www.mdpi.com/2072-6694/15/24/5730

Internet

https://www.mdpi.com/2072-6694/15/24/5730

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