Antiviral Efficacy of RNase H-Dependent Gapmer Antisense Oligonucleotides against Japanese Encephalitis Virus

Antiviral Efficacy of RNase H-Dependent Gapmer Antisense Oligonucleotides against Japanese Encephalitis Virus

RNase H-dependent gapmer antisense oligonucleotides (ASOs) are a promising therapeutic approach via sequence-specific binding to and degrading target RNAs. However, the efficacy and mechanism of antiviral gapmer ASOs have remained unclear. Here, we investigated the inhibitory effects of gapmer ASOs...

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Bibliographic Details
Main Authors: Shunsuke Okamoto, Yusuke Echigoya, Ayaka Tago, Takao Segawa, Yukita Sato, Takuya Itou
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:International Journal of Molecular Sciences
Subjects:
Japanese encephalitis virus
gapmer antisense oligonucleotide
locked nucleic acid (LNA)
antiviral
RNase H
3′ UTR stem-loop region
Online Access:https://www.mdpi.com/1422-0067/24/19/14846

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https://www.mdpi.com/1422-0067/24/19/14846

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