Genetic variation in the <it>Catechol-O-Methyltransferase (COMT) </it>gene and morphine requirements in cancer patients with pain

<p>Abstract</p> <p>Background</p> <p>Genetic variation contributes to differences in pain sensitivity and response to different analgesics. Catecholamines are involved in the modulation of pain and are partly metabolized by the catechol-O-methyltransferase (COMT) enzyme...

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Bibliographic Details
Main Authors: Kaasa Stein, Skorpen Frank, Sato Hiroe, Ross Joy R, Rakvåg Trude T, Klepstad Pål
Format: Article
Language:English
Published: SAGE Publishing 2008-12-01
Series:Molecular Pain
Online Access:http://stephenslab.uchicago.edu/home.html