Recovery kinetics of dual AAV-mediated human otoferlin expression

Recovery kinetics of dual AAV-mediated human otoferlin expression

Deafness-causing deficiencies in otoferlin (OTOF) have been addressed preclinically using dual adeno-associated virus (AAV)-based approaches. However, timing of transduction, recombination of mRNA, and protein expression with dual hybrid AAV methods methods have not previously been characterized. He...

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Bibliographic Details
Main Authors: Jonathan B. Sellon, Kathy S. So, Andrew D'Arcangelo, Sarah Cancelarich, Meghan C. Drummond, Peter G. Slade, Ning Pan, Tyler M. Gibson, Tian Yang, Joseph C. Burns, Adam T. Palermo, Lars Becker
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
DFNB9
otoferlin
OTOF
ex vivo
explant
dual hybrid
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2024.1376128/full

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https://www.frontiersin.org/articles/10.3389/fnmol.2024.1376128/full

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