Botulinum toxin type A promotes microglial M2 polarization and suppresses chronic constriction injury-induced neuropathic pain through the P2X7 receptor

Botulinum toxin type A promotes microglial M2 polarization and suppresses chronic constriction injury-induced neuropathic pain through the P2X7 receptor

Abstract Background Switching microglial polarization from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype represents a novel therapeutic strategy for neuropathic pain (NP). This study aims to investigate whether botulinum toxin type A (BTX-A) regulates microglial M1/M2 polar...

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Bibliographic Details
Main Authors: Xianwei Gui, Hansen Wang, Lanxiang Wu, Sheng Tian, Xuan Wang, Heqing Zheng, Wei Wu
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Cell & Bioscience
Subjects:
Botulinum toxin type A
Neuropathic pain
Microglia
M1/M2 polarization
P2X7 receptor
Online Access:http://link.springer.com/article/10.1186/s13578-020-00405-3

Internet

http://link.springer.com/article/10.1186/s13578-020-00405-3

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