Novel Aminopyrimidine-2,4-diones, 2-Thiopyrimidine-4-ones, and 6-Arylpteridines as Dual-Target Inhibitors of BRD4/PLK1: Design, Synthesis, Cytotoxicity, and Computational Studies

Novel Aminopyrimidine-2,4-diones, 2-Thiopyrimidine-4-ones, and 6-Arylpteridines as Dual-Target Inhibitors of BRD4/PLK1: Design, Synthesis, Cytotoxicity, and Computational Studies

Structural-based drug design and solvent-free synthesis were combined to obtain three novel series of 5-arylethylidene-aminopyrimidine-2,4-diones (<b>4</b>, <b>5a</b>–<b>c</b>, <b>6a</b>,<b>b</b>), 5-arylethylidene-amino-2-thiopyrimidine-4-...

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Bibliographic Details
Main Authors: Samar El-Kalyoubi, Samiha A. El-Sebaey, Sherin M. Elfeky, Hanan A. AL-Ghulikah, Mona S. El-Zoghbi
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Pharmaceuticals
Subjects:
pyrimidines
pteridines
BRD4 inhibitors
PLK1 inhibitors
cytotoxicity
computational studies
Online Access:https://www.mdpi.com/1424-8247/16/9/1303

Internet

https://www.mdpi.com/1424-8247/16/9/1303

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