Expression of Human Endogenous Retrovirus-K in Spinal and Bulbar Muscular Atrophy

Expression of Human Endogenous Retrovirus-K in Spinal and Bulbar Muscular Atrophy

Background: Spinal and Bulbar Muscular Atrophy (SBMA) is caused by the extension of the polyglutamine tract within the androgen receptor (AR) gene, and results in a multisystem presentation, including the degeneration of lower motor neurons. The androgen receptor (AR) is known to modulate the expres...

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Bibliographic Details
Main Authors: Cody Rex, Marie-Josée Nadeau, Renée Douville, Kerri Schellenberg
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Neurology
Subjects:
endogenous retrovirus-K (ERVK)
spinal and bulbar muscular atrophy (SBMA)
amyotrophic lateral sclerosis (ALS)
peripheral blood mononuclear cells (PBMC)
inflammation
DNA damage
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2019.00968/full

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https://www.frontiersin.org/article/10.3389/fneur.2019.00968/full

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