RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells

RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells

Abstract Tissue homeostasis is maintained after stress by engaging and activating the hematopoietic stem and progenitor compartments in the blood. Hematopoietic stem cells (HSCs) are essential for long-term repopulation after secondary transplantation. Here, using a conditional knockout mouse model,...

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Bibliographic Details
Main Authors: Florisela Herrejon Chavez, Hanzhi Luo, Paolo Cifani, Alli Pine, Eren L. Chu, Suhasini Joshi, Ersilia Barin, Alexandra Schurer, Mandy Chan, Kathryn Chang, Grace Y. Q. Han, Aspen J. Pierson, Michael Xiao, Xuejing Yang, Lindsey M. Kuehm, Yuning Hong, Diu T. T. Nguyen, Gabriela Chiosis, Alex Kentsis, Christina Leslie, Ly P. Vu, Michael G. Kharas
Format: Article
Language:English
Published: Nature Portfolio 2023-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-38001-x

Internet

https://doi.org/10.1038/s41467-023-38001-x

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