Overcoming the Drawbacks of Sulpiride by Means of New Crystal Forms

Overcoming the Drawbacks of Sulpiride by Means of New Crystal Forms

This study aims at developing new multicomponent crystal forms of sulpiride, an antipsychotic drug. The main goal was to improve its solubility since it belongs to class IV of the BCS. Nine new adducts were obtained by combining the active pharmaceutical ingredient with acid coformers: a salt cocrys...

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Bibliographic Details
Main Authors: Rebecca Birolo, Federica Bravetti, Simone Bordignon, Ilenia D’Abbrunzo, Paolo P. Mazzeo, Beatrice Perissutti, Alessia Bacchi, Michele R. Chierotti, Roberto Gobetto
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Pharmaceutics
Subjects:
sulpiride
improved solubility
crystal engineering
solid-state NMR
X-ray diffraction
molecular salts
Online Access:https://www.mdpi.com/1999-4923/14/9/1754

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https://www.mdpi.com/1999-4923/14/9/1754

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