Semaphorin 5A suppresses ferroptosis through activation of PI3K-AKT-mTOR signaling in rheumatoid arthritis

Semaphorin 5A suppresses ferroptosis through activation of PI3K-AKT-mTOR signaling in rheumatoid arthritis

Abstract Abnormal activation of synovial fibroblasts (SFs) plays an important role in rheumatoid arthritis (RA), the mechanism of which remains unknown. The purpose of our study is to comprehensively and systematically explore the mechanism for Semaphorin 5A-mediated abnormal SF activation in RA. He...

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Bibliographic Details
Main Authors: Qi Cheng, Mo Chen, Mengdan Liu, Xin Chen, Lingjiang Zhu, Jieying Xu, Jing Xue, Huaxiang Wu, Yan Du
Format: Article
Language:English
Published: Nature Publishing Group 2022-07-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05065-4

Internet

https://doi.org/10.1038/s41419-022-05065-4

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