Structure and dynamics of the Arabidopsis O-fucosyltransferase SPINDLY

Structure and dynamics of the Arabidopsis O-fucosyltransferase SPINDLY

Kumar and colleagues report cryo-EM structures of Arabidopsis O-fucosyltransferase SPINDLY in its apo and GDP-fucose bound states, revealing distinct active-site features enabling GDP-fucose recognition and surprisingly dynamic conformations that regulate its enzymatic activity.

Bibliographic Details
Main Authors: Shivesh Kumar, Yan Wang, Ye Zhou, Lucas Dillard, Fay-Wei Li, Carly A. Sciandra, Ning Sui, Rodolfo Zentella, Emily Zahn, Jeffrey Shabanowitz, Donald F. Hunt, Mario J. Borgnia, Alberto Bartesaghi, Tai-ping Sun, Pei Zhou
Format: Article
Language:English
Published: Nature Portfolio 2023-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-37279-1

Internet

https://doi.org/10.1038/s41467-023-37279-1

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