Protective role of Cav-1 in pneumolysin-induced endothelial barrier dysfunction

Protective role of Cav-1 in pneumolysin-induced endothelial barrier dysfunction

Pneumolysin (PLY) is a bacterial pore forming toxin and primary virulence factor of Streptococcus pneumonia, a major cause of pneumonia. PLY binds cholesterol-rich domains of the endothelial cell (EC) plasma membrane resulting in pore assembly and increased intracellular (IC) Ca2+ levels that compro...

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Bibliographic Details
Main Authors: Robert K. Batori, Feng Chen, Zsuzsanna Bordan, Stephen Haigh, Yunchao Su, Alexander D. Verin, Scott A. Barman, David W. Stepp, Trinad Chakraborty, Rudolf Lucas, David J. R. Fulton
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Immunology
Subjects:
caveolin-1
pneumolysin
calcium-influx
barrier-function
endocytosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.945656/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.945656/full

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