Parthenolide and arsenic trioxide co-trigger autophagy-accompanied apoptosis in hepatocellular carcinoma cells

Parthenolide and arsenic trioxide co-trigger autophagy-accompanied apoptosis in hepatocellular carcinoma cells

Although arsenic trioxide (ATO) shows a strong anti-tumor effect in the treatment of acute promyelocytic leukemia, it does not benefit patients with hepatocellular carcinoma (HCC). Thus, combination therapy is proposed to enhance the efficacy of ATO. Parthenolide (PTL), a natural compound, selective...

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Bibliographic Details
Main Authors: Juan Yi, Xia Gong, Xiao-Yang Yin, Li Wang, Jin-Xia Hou, Jing Chen, Bei Xie, Gang Chen, Li-Na Wang, Xiao-Yuan Wang, Da-Chun Wang, Hu-Lai Wei
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Oncology
Subjects:
arsenic trioxide
parthenolide
apoptosis
autophagy
hepatocellular carcinoma
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.988528/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.988528/full

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