4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to promote cuproptosis in colorectal cancer

4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to promote cuproptosis in colorectal cancer

Cuproptosis, a novel copper-induced cell death pathway, is linked to mitochondrial respiration and mediated by protein lipoylation. The discovery of cuproptosis unfolds new areas of investigation, particularly in cancers. The present study aimed to explore the role of cuproptosis in colorectal cance...

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Bibliographic Details
Main Authors: Wenchang Yang, Yaxin Wang, Yongzhou Huang, Jiaxian Yu, Tao Wang, Chengguo Li, Lei Yang, Peng Zhang, Liang Shi, Yuping Yin, Kaixiong Tao, Ruidong Li
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Cuproptosis
4-Octyl itaconate
Aerobic glycolysis
Colorectal cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223000896

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http://www.sciencedirect.com/science/article/pii/S0753332223000896

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