GM-CSF-mediated inducement of bone marrow MDSCs by TSA and effect on survival of graft in mice

GM-CSF-mediated inducement of bone marrow MDSCs by TSA and effect on survival of graft in mice

Abstract Objective This study analyzed the effect of HDAC inhibitor, trichostatin A (TSA), in inducing granulocyte–macrophage colony-stimulating factor (GM-CSF)-mediated bone marrow (BM) cell differentiation to myeloid-derived suppressor cells (MDSCs) in vitro and in vivo. Methods BM cell differenti...

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Bibliographic Details
Main Authors: Shuguang Zhao, Shaohua Li, Jingci Yang, Weinian Gao, Ziying Chen
Format: Article
Language:English
Published: BMC 2022-08-01
Series:European Journal of Medical Research
Subjects:
Myeloid-derived suppressor cells
GM-CSF
HDAC inhibitor
Differentiation
Transplant
Online Access:https://doi.org/10.1186/s40001-022-00788-8

Internet

https://doi.org/10.1186/s40001-022-00788-8

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