Synthesis and Evaluation of Phenylxanthine Derivatives as Potential Dual A2AR Antagonists/MAO-B Inhibitors for Parkinson’s Disease

Synthesis and Evaluation of Phenylxanthine Derivatives as Potential Dual A2AR Antagonists/MAO-B Inhibitors for Parkinson’s Disease

The aim of this research was to prove the speculation that phenylxanthine (PX) derivatives possess adenosine A2A receptor (A2AR)-blocking properties and to screening and evaluate these PX derivatives as dual A2AR antagonists/MAO-B inhibitors for Parkinson′s disease. To explore this hypothesis, two s...

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Bibliographic Details
Main Authors: Xuebao Wang, Chao Han, Yong Xu, Kaiqi Wu, Shuangya Chen, Mangsha Hu, Luyao Wang, Yun Ye, Faqing Ye
Format: Article
Language:English
Published: MDPI AG 2017-06-01
Series:Molecules
Subjects:
adenosine A2AR antagonist
monoamine oxidase B inhibitor
phenylxanthine derivatives
parkinson′s disease
Online Access:http://www.mdpi.com/1420-3049/22/6/1010

Internet

http://www.mdpi.com/1420-3049/22/6/1010

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