Mismatch repair-signature mutations activate gene enhancers across human colorectal cancer epigenomes

Mismatch repair-signature mutations activate gene enhancers across human colorectal cancer epigenomes

Commonly-mutated genes have been found for many cancers, but less is known about mutations in cis-regulatory elements. We leverage gains in tumor-specific enhancer activity, coupled with allele-biased mutation detection from H3K27ac ChIP-seq data, to pinpoint potential enhancer-activating mutations...

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Bibliographic Details
Main Authors: Stevephen Hung, Alina Saiakhova, Zachary J Faber, Cynthia F Bartels, Devin Neu, Ian Bayles, Evelyn Ojo, Ellen S Hong, W Dean Pontius, Andrew R Morton, Ruifu Liu, Matthew F Kalady, David N Wald, Sanford Markowitz, Peter C Scacheri
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-02-01
Series:eLife
Subjects:
gene enhancer
cis-regulatory mutation
colorectal cancer
Online Access:https://elifesciences.org/articles/40760

Internet

https://elifesciences.org/articles/40760

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