HIV-1 gp120 Promotes Lysosomal Exocytosis in Human Schwann Cells

HIV-1 gp120 Promotes Lysosomal Exocytosis in Human Schwann Cells

Human immunodeficiency virus type 1 (HIV-1) associated neuropathy is the most common neurological complication of HIV-1, with debilitating pain affecting the quality of life. HIV-1 gp120 plays an important role in the pathogenesis of HIV neuropathy via direct neurotoxic effects or indirect pro-infla...

Full description

Bibliographic Details
Main Authors: Gaurav Datta, Nicole M. Miller, Zahra Afghah, Jonathan D. Geiger, Xuesong Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
gp120
lysosome exocytosis
P2X4
ATP
Schwann cell
DRG neuron
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00329/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2019.00329/full

Similar Items