Human OPRM1 and murine Oprm1 promoter driven viral constructs for genetic access to μ-opioidergic cell types

Human OPRM1 and murine Oprm1 promoter driven viral constructs for genetic access to μ-opioidergic cell types

Abstract With concurrent global epidemics of chronic pain and opioid use disorders, there is a critical need to identify, target and manipulate specific cell populations expressing the mu-opioid receptor (MOR). However, available tools and transgenic models for gaining long-term genetic access to MO...

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Bibliographic Details
Main Authors: Gregory J. Salimando, Sébastien Tremblay, Blake A. Kimmey, Jia Li, Sophie A. Rogers, Jessica A. Wojick, Nora M. McCall, Lisa M. Wooldridge, Amrith Rodrigues, Tito Borner, Kristin L. Gardiner, Selwyn S. Jayakar, Ilyas Singeç, Clifford J. Woolf, Matthew R. Hayes, Bart C. De Jonghe, F. Christian Bennett, Mariko L. Bennett, Julie A. Blendy, Michael L. Platt, Kate Townsend Creasy, William R. Renthal, Charu Ramakrishnan, Karl Deisseroth, Gregory Corder
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-41407-2

Internet

https://doi.org/10.1038/s41467-023-41407-2

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