Apolipoprotein E4 Is Associated with Right Ventricular Dysfunction in Dilated Cardiomyopathy—An Animal and In-Human Comparative Study

Apolipoprotein E4 Is Associated with Right Ventricular Dysfunction in Dilated Cardiomyopathy—An Animal and In-Human Comparative Study

ApoE abnormality represents a well-known risk factor for cardiovascular diseases. Beyond its role in lipid metabolism, novel studies demonstrate a complex involvement of apoE in membrane homeostasis and signaling as well as in nuclear transcription. Due to the large spread of apoE isoforms in the hu...

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Bibliographic Details
Main Authors: Rodica Diaconu, Nicole Schaaps, Mamdouh Afify, Peter Boor, Anne Cornelissen, Roberta A. Florescu, Sakine Simsekyilmaz, Teddy El-Khoury, David Schumacher, Mihai Ioana, Ioana Streata, Constantin Militaru, Ionut Donoiu, Felix Vogt, Elisa A. Liehn
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
apoE
cardiovascular models
dilated cardiomyopathy
right ventricular systolic dysfunction
ε4 allele
Online Access:https://www.mdpi.com/1422-0067/22/18/9688

Internet

https://www.mdpi.com/1422-0067/22/18/9688

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