USP47-Mediated Deubiquitination and Stabilization of TCEA3 Attenuates Pyroptosis and Apoptosis of Colorectal Cancer Cells Induced by Chemotherapeutic Doxorubicin

USP47-Mediated Deubiquitination and Stabilization of TCEA3 Attenuates Pyroptosis and Apoptosis of Colorectal Cancer Cells Induced by Chemotherapeutic Doxorubicin

The ubiquitin–proteasome system regulates a variety of cellular processes including growth, differentiation and apoptosis. While E1, E2, and E3 are responsible for the conjugation of ubiquitin to substrates, deubiquitinating enzymes (DUBs) reverse the process to remove ubiquitin and edit ubiquitin c...

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Bibliographic Details
Main Authors: Xiaodan Hou, Jun Xia, Yuan Feng, Long Cui, Yili Yang, Peng Yang, Xin Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Pharmacology
Subjects:
USP47
TCEA3
pyroptosis
apoptosis
colorectal cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.713322/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.713322/full

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