Molecular and clinical analyses of PHF6 mutant myeloid neoplasia provide their pathogenesis and therapeutic targeting

Molecular and clinical analyses of PHF6 mutant myeloid neoplasia provide their pathogenesis and therapeutic targeting

Abstract PHF6 mutations (PHF6 MT) are identified in various myeloid neoplasms (MN). However, little is known about the precise function and consequences of PHF6 in MN. Here we show three main findings in our comprehensive genomic and proteomic study. Firstly, we show a different pattern of genes cor...

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Bibliographic Details
Main Authors: Yasuo Kubota, Xiaorong Gu, Laila Terkawi, Juraj Bodo, Bartlomiej P. Przychodzen, Hussein Awada, Nakisha Williams, Carmelo Gurnari, Naomi Kawashima, Mai Aly, Arda Durmaz, Minako Mori, Ben Ponvilawan, Tariq Kewan, Waled Bahaj, Manja Meggendorfer, Babal K. Jha, Valeria Visconte, Heesun J. Rogers, Torsten Haferlach, Jaroslaw P. Maciejewski
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-46134-w

Internet

https://doi.org/10.1038/s41467-024-46134-w

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