Clonal hematopoiesis in sickle cell disease

Clonal hematopoiesis in sickle cell disease

BACKGROUND Curative gene therapies for sickle cell disease (SCD) are currently undergoing clinical evaluation. The occurrence of myeloid malignancies in these trials has prompted safety concerns. Individuals with SCD are predisposed to myeloid malignancies, but the underlying causes remain undefined...

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Bibliographic Details
Main Authors: L. Alexander Liggett, Liam D. Cato, Joshua S. Weinstock, Yingze Zhang, S. Mehdi Nouraie, Mark T. Gladwin, Melanie E. Garrett, Allison Ashley-Koch, Marilyn J. Telen, Brian Custer, Shannon Kelly, Carla L. Dinardo, Ester C. Sabino, Paula Loureiro, Anna B. Carneiro-Proietti, Cláudia Maximo, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Alexander P. Reiner, Gonçalo R. Abecasis, David A. Williams, Pradeep Natarajan, Alexander G. Bick, Vijay G. Sankaran
Format: Article
Language:English
Published: American Society for Clinical Investigation 2022-02-01
Series:The Journal of Clinical Investigation
Subjects:
Hematology
Online Access:https://doi.org/10.1172/JCI156060

Internet

https://doi.org/10.1172/JCI156060

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