Antibody:CD47 ratio regulates macrophage phagocytosis through competitive receptor phosphorylation

Antibody:CD47 ratio regulates macrophage phagocytosis through competitive receptor phosphorylation

Summary: Cancer immunotherapies often modulate macrophage effector function by introducing either targeting antibodies that activate Fcγ receptors (FcγRs) or blocking antibodies that disrupt inhibitory SIRPα-CD47 engagement. However, how these competing signals are integrated is poorly understood, r...

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Bibliographic Details
Main Authors: Emily C. Suter, Eva M. Schmid, Andrew R. Harris, Erik Voets, Brian Francica, Daniel A. Fletcher
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Cell Reports
Subjects:
macrophage
phagocytosis
Fc receptor
therapeutic antibody
SIRPα
CD47
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721010214

Internet

http://www.sciencedirect.com/science/article/pii/S2211124721010214

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