Cardioprotection by Hypothyroidism Is Not Mediated by Favorable Hemodynamics—Role of Canonical Thyroid Hormone Receptor Alpha Signaling

Cardioprotection by Hypothyroidism Is Not Mediated by Favorable Hemodynamics—Role of Canonical Thyroid Hormone Receptor Alpha Signaling

Hypothyroidism has been shown to reduce infarct size in rats, but the underlying mechanisms are unclear. We used isolated pressure-constant perfused hearts of control, hypothyroid and hyperthyroid mice and measured infarct size, functional parameters and phosphorylation of key molecules in cardiopro...

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Bibliographic Details
Main Authors: Janina Pape, Helena Kerp, Helmut R. Lieder, Daniela Geist, Georg Sebastian Hönes, Lars C. Moeller, Petra Kleinbongard, Dagmar Führer
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
cardioprotection
thyroid hormone receptor
ischemia/reperfusion injury
isolated heart
thyroid hormone
hypothyroidism
Online Access:https://www.mdpi.com/1422-0067/23/21/13340

Internet

https://www.mdpi.com/1422-0067/23/21/13340

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