A Novel Stochastic Multi-Scale Model of Francisella tularensis Infection to Predict Risk of Infection in a Laboratory

A Novel Stochastic Multi-Scale Model of Francisella tularensis Infection to Predict Risk of Infection in a Laboratory

We present a multi-scale model of the within-phagocyte, within-host and population-level infection dynamics of Francisella tularensis, which extends the mechanistic one proposed by Wood et al. (2014). Our multi-scale model incorporates key aspects of the interaction between host phagocytes and extra...

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Bibliographic Details
Main Authors: Jonathan Carruthers, Martín López-García, Joseph J. Gillard, Thomas R. Laws, Grant Lythe, Carmen Molina-París
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Microbiology
Subjects:
Francisella tularensis
Markov process
multi-scale model
dose response probability
mean response time
zonal ventilation model
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.01165/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2018.01165/full

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