Extracellular vesicles derived from mesenchymal stem cells alleviate neuroinflammation and mechanical allodynia in interstitial cystitis rats by inhibiting NLRP3 inflammasome activation

Extracellular vesicles derived from mesenchymal stem cells alleviate neuroinflammation and mechanical allodynia in interstitial cystitis rats by inhibiting NLRP3 inflammasome activation

Abstract Background Neuroinflammation in spinal dorsal horn (SDH) plays an important role in the pathogenesis of interstitial cystitis/bladder pain syndrome (IC/BPS). Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) exert potent anti-inflammatory activities in the treatment of various...

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Bibliographic Details
Main Authors: Chi Zhang, Yong Huang, Fubing Ouyang, Minzhi Su, Wenbiao Li, Jialiang Chen, Hengjun Xiao, Xiangfu Zhou, Bolong Liu
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Journal of Neuroinflammation
Subjects:
Interstitial cystitis/bladder pain syndrome
Mesenchymal stem cell
Extracellular vesicle
NLRP3 inflammasome
Neuroinflammation
Online Access:https://doi.org/10.1186/s12974-022-02445-7

Internet

https://doi.org/10.1186/s12974-022-02445-7

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