Maternal diet-induced obesity during pregnancy alters lipid supply to mouse E18.5 fetuses and changes the cardiac tissue lipidome in a sex-dependent manner

Maternal diet-induced obesity during pregnancy alters lipid supply to mouse E18.5 fetuses and changes the cardiac tissue lipidome in a sex-dependent manner

Maternal obesity during pregnancy has immediate and long-term detrimental effects on the offspring heart. In this study, we characterized the cardiac and circulatory lipid profiles in late gestation E18.5 fetuses of diet-induced obese pregnant mice and established the changes in lipid abundance and...

Full description

Bibliographic Details
Main Authors: Lucas C Pantaleão, Isabella Inzani, Samuel Furse, Elena Loche, Antonia Hufnagel, Thomas Ashmore, Heather L Blackmore, Benjamin Jenkins, Asha A M Carpenter, Ania Wilczynska, Martin Bushell, Albert Koulman, Denise S Fernandez-Twinn, Susan E Ozanne
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-01-01
Series:eLife
Subjects:
maternal obesity
fetal heart
heart metabolism
lipidomics
transcriptomics
Online Access:https://elifesciences.org/articles/69078

Internet

https://elifesciences.org/articles/69078

Similar Items