Polygenic Hazard Score Associated Multimodal Brain Networks Along the Alzheimer’s Disease Continuum

Polygenic Hazard Score Associated Multimodal Brain Networks Along the Alzheimer’s Disease Continuum

BackgroundLate-onset Alzheimer’s disease (AD) is a polygenic neurodegenerative disease. Identifying the neuroimaging phenotypes behind the genetic predisposition of AD is critical to the understanding of AD pathogenesis. Two major questions which previous studies have led to are: (1) should the gene...

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Bibliographic Details
Main Authors: Kaicheng Li, Zening Fu, Shile Qi, Xiao Luo, Qingze Zeng, Xiaopei Xu, Peiyu Huang, Minming Zhang, Vince D. Calhoun
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
polygenic hazard score
supervised multimodal fusion
default mode network
executive control network
visuospatial network
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.725246/full

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https://www.frontiersin.org/articles/10.3389/fnagi.2021.725246/full

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