Characterisation of the in vitro activity of a Nitazoxanide-N-methyl-1H-benzimidazole hybrid molecule against albendazole and nitazoxanide susceptible and resistant strains of Giardia intestinalis and its in vivo giardicidal activity

Characterisation of the in vitro activity of a Nitazoxanide-N-methyl-1H-benzimidazole hybrid molecule against albendazole and nitazoxanide susceptible and resistant strains of Giardia intestinalis and its in vivo giardicidal activity

BACKGROUND It was previously demonstrated that CMC-20, a nitazoxanide and N-methyl-1H-benzimidazole hybrid molecule, had higher in vitro activity against Giardia intestinalis WB strain than metronidazole and albendazole and similar to nitazoxanide. OBJETIVES To evaluate the in vitro activity of C...

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Bibliographic Details
Main Authors: Félix Matadamas-Martínez, Benjamín Nogueda-Torres, Rafael Castillo, Alicia Hernández-Campos, María de la Luz Barrera-Valdes, Gloria León-Ávila, José Manuel Hernández, Lilián Yépez-Mulia
Format: Article
Language:English
Published: Fundação Oswaldo Cruz (FIOCRUZ)
Series:Memorias do Instituto Oswaldo Cruz
Subjects:
giardicidal activity
hybrid molecule
resistant strains
cytoskeletal proteins
in vivo activity
Online Access:http://www.scielo.br/pdf/mioc/v115/1678-8060-mioc-115-e190348.pdf

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http://www.scielo.br/pdf/mioc/v115/1678-8060-mioc-115-e190348.pdf

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