Characterisation of the in vitro activity of a Nitazoxanide-N-methyl-1H-benzimidazole hybrid molecule against albendazole and nitazoxanide susceptible and resistant strains of Giardia intestinalis and its in vivo giardicidal activity

Characterisation of the in vitro activity of a Nitazoxanide-N-methyl-1H-benzimidazole hybrid molecule against albendazole and nitazoxanide susceptible and resistant strains of Giardia intestinalis and its in vivo giardicidal activity

BACKGROUND It was previously demonstrated that CMC-20, a nitazoxanide and N-methyl-1H-benzimidazole hybrid molecule, had higher in vitro activity against Giardia intestinalis WB strain than metronidazole and albendazole and similar to nitazoxanide. OBJETIVES To evaluate the in vitro activity of C...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron: Félix Matadamas-Martínez, Benjamín Nogueda-Torres, Rafael Castillo, Alicia Hernández-Campos, María de la Luz Barrera-Valdes, Gloria León-Ávila, José Manuel Hernández, Lilián Yépez-Mulia
Fformat: Erthygl
Iaith:English
Cyhoeddwyd: Fundação Oswaldo Cruz (FIOCRUZ)
Cyfres:Memorias do Instituto Oswaldo Cruz
Pynciau:
giardicidal activity
hybrid molecule
resistant strains
cytoskeletal proteins
in vivo activity
Mynediad Ar-lein:http://www.scielo.br/pdf/mioc/v115/1678-8060-mioc-115-e190348.pdf

Rhyngrwyd

http://www.scielo.br/pdf/mioc/v115/1678-8060-mioc-115-e190348.pdf

Eitemau Tebyg