Transient CD4+ T cell depletion during suppressive ART reduces the HIV reservoir in humanized mice.

Transient CD4+ T cell depletion during suppressive ART reduces the HIV reservoir in humanized mice.

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Lifelong treatment is required for people living with HIV as current antiretroviral therapy (ART) does not eradicate HIV infection. Latently infected cells are essentially indistinguishable from uninfected cells and cannot be depleted by currently available approaches. This study evaluated antibody...

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Bibliographic Details
Main Authors: Lijun Ling, Chandrav De, Rae Ann Spagnuolo, Nurjahan Begum, Shane D Falcinelli, Nancie M Archin, Martina Kovarova, Guido Silvestri, Angela Wahl, David M Margolis, J Victor Garcia
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-12-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011824&type=printable

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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1011824&type=printable

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