Deletion of the Imprinted Gene Grb10 Promotes Hematopoietic Stem Cell Self-Renewal and Regeneration

Deletion of the Imprinted Gene Grb10 Promotes Hematopoietic Stem Cell Self-Renewal and Regeneration

Imprinted genes are differentially expressed by adult stem cells, but their functions in regulating adult stem cell fate are incompletely understood. Here we show that growth factor receptor-bound protein 10 (Grb10), an imprinted gene, regulates hematopoietic stem cell (HSC) self-renewal and regener...

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Bibliographic Details
Main Authors: Xiao Yan, Heather A. Himburg, Katherine Pohl, Mamle Quarmyne, Evelyn Tran, Yurun Zhang, Tiancheng Fang, Jenny Kan, Nelson J. Chao, Liman Zhao, Phuong L. Doan, John P. Chute
Format: Article
Language:English
Published: Elsevier 2016-11-01
Series:Cell Reports
Subjects:
hematopoietic stem cells
imprinted gene
adaptor protein
self-renewal
regeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716314280

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http://www.sciencedirect.com/science/article/pii/S2211124716314280

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