Defective DNAM-1 Dependent Cytotoxicity in Hepatocellular Carcinoma-Infiltrating NK Cells

Defective DNAM-1 Dependent Cytotoxicity in Hepatocellular Carcinoma-Infiltrating NK Cells

Background: Natural killer (NK) cells play a key role in immune surveillance and response to tumors, their function regulated by NK cell receptors and their ligands. The DNAM-1 activating receptor recognizes the CD155 molecule expressed in several tumor cells, such as hepatocellular carcinoma (HCC)....

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Bibliographic Details
Main Authors: Stefania Mantovani, Stefania Varchetta, Dalila Mele, Roberta Maiello, Matteo Donadon, Cristiana Soldani, Barbara Franceschini, Guido Torzilli, Giuseppe Tartaglia, Marcello Maestri, Gaetano Piccolo, Matteo Barabino, Enrico Opocher, Stefano Bernuzzi, Mario U. Mondelli, Barbara Oliviero
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Cancers
Subjects:
natural killer cells
DNAM-1
PVR
hepatocellular carcinoma
Online Access:https://www.mdpi.com/2072-6694/14/16/4060

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https://www.mdpi.com/2072-6694/14/16/4060

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