Selective modification of diclofenac to reduce the adverse effects; A computer-aided drug design approach

Selective modification of diclofenac to reduce the adverse effects; A computer-aided drug design approach

Diclofenac (DCF) is a non-steroidal anti-inflammatory drug (NSAID), commonly used for the treatment of pain. It can inhibit prostaglandin synthesis by blocking cyclooxygenase (COX). It shows some crucial side effects like gastrointestinal, cardiovascular, renal, and liver injury. The gastrointestina...

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Bibliographic Details
Main Authors: Md. Kamrul Hasan, Shamima Akhter, Kaniz Fatema, Md. Rezaul Hossain, Tamanna Sultana, Monir Uzzaman
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Informatics in Medicine Unlocked
Subjects:
Diclofenac
Cyclooxygenase
Molecular docking and dynamic simulation
ADMET and PASS prediction
Online Access:http://www.sciencedirect.com/science/article/pii/S2352914823000011

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http://www.sciencedirect.com/science/article/pii/S2352914823000011

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