The translation regulatory subunit eIF3f controls the kinase-dependent mTOR signaling required for muscle differentiation and hypertrophy in mouse.

The translation regulatory subunit eIF3f controls the kinase-dependent mTOR signaling required for muscle differentiation and hypertrophy in mouse.

The mTORC1 pathway is required for both the terminal muscle differentiation and hypertrophy by controlling the mammalian translational machinery via phosphorylation of S6K1 and 4E-BP1. mTOR and S6K1 are connected by interacting with the eIF3 initiation complex. The regulatory subunit eIF3f plays a m...

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Bibliographic Details
Main Authors: Alfredo Csibi, Karen Cornille, Marie-Pierre Leibovitch, Anne Poupon, Lionel A Tintignac, Anthony M J Sanchez, Serge A Leibovitch
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-02-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2813880?pdf=render

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http://europepmc.org/articles/PMC2813880?pdf=render

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