A time-resolved clonogenic assay for improved cell survival and RBE measurements

A time-resolved clonogenic assay for improved cell survival and RBE measurements

Purpose: The in vitro clonogenic assay (IVCA) is the mainstay of quantitative radiobiology. Here, we investigate the benefit of a time-resolved IVCA version (trIVCA) to improve the quantification of clonogenic survival and relative biological effectiveness (RBE) by analyzing cell colony growth behav...

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Bibliographic Details
Main Authors: Robin A Koch, Marc Boucsein, Stephan Brons, Markus Alber, Emanuel Bahn
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Clinical and Translational Radiation Oncology
Subjects:
Radiobiology
Dose-response relationship, radiation
Relative biological effectiveness
Heavy ion radiotherapy
Time-lapse imaging
Supervised machine learning
Online Access:http://www.sciencedirect.com/science/article/pii/S2405630823000873

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http://www.sciencedirect.com/science/article/pii/S2405630823000873

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